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APOA4

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
Protein class

Candidate cardiovascular disease genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Proximal enterocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO, CACO-2, Hep G2, NB-4, RPMI-8226, SH-SY5Y)

Interaction

Homodimer.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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