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ARAP3

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Horizontal cells, Adipocytes, Hepatic stellate cells, Endothelial cells, Microglial cells)

Immune cell specificity

Group enriched (eosinophil, neutrophil)

Cell line specificity

Cell line enhanced (EFO-21, HUVEC TERT2, TIME)

Interaction

Interacts (via SAM domain) with INPPL1/SHIP2.

Molecular function

GTPase activation

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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