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ARG2

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.
Protein class

Cancer-related genes, Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Syncytiotrophoblasts, Proximal tubular cells, Basal prostatic cells, Collecting duct cells, Urothelial cells, Glandular and luminal cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HAP1)

Interaction

Homotrimer.

Molecular function

Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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