Cancer-related genes, Human disease related genes
Intracellular
Cell type enhanced (granulocytes, Granulosa cells, Microglial cells)
Low immune cell specificity
Cell line enhanced (HEL, HL-60, HMC-1, JURKAT, U-937)
Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1 (By similarity). Interacts with PARVB. Interacts with BIN2. Identified in a complex with BIN2 and GIT2.
Guanine-nucleotide releasing factor
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For Research Use Only. Not For Clinical Use.