ARL2BP

ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise afunctionally distinct group of the ARF family of RAS-related GTPases. ARL2BP binds to ARL2.GTP with high affinity but doesnot interact with ARL2.GDP, activated ARF, or RHO proteins. The lack ofdetectable membrane association of ARL2BP or ARL2 upon activation of ARL2 issuggestive of actions distinct from those of the ARFs. ARL2BP is considered tobe the first ARL2-specific effector identified, due to its interactionwith ARL2.GTP but lack of ARL2 GTPase-activating protein activity. ARL2BP,together with ARL2, plays a role in the nuclear translocation, retention andtranscriptional activity of STAT3. ARL2BP may play a role as an effector of ARL2.