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ART4

This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.
Protein class

Blood group antigen proteins, CD markers, Enzymes, Metabolic proteins

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Hepatic stellate cells, Erythroid cells, Hepatocytes, Cholangiocytes, Endothelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AN3-CA, HEL, Hep G2, HUVEC TERT2)

Molecular function

Blood group antigen, Glycosyltransferase, Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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