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ASNA1
This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion.
Protein class
Transporters
Predicted location
Intracellular
Single cell type specificity
Group enriched (Hofbauer cells, Syncytiotrophoblasts, Cytotrophoblasts, Extravillous trophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (By similarity). Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40 (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:32910895). Within the complex, CAMLG and GET1 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (PubMed:32910895). Interacts with CAMLG (via N-terminus) (By similarity). GET3 shows a higher affinity for CAMLG than for GET1 (PubMed:24392163). Interacts with SERP1 and SEC61B (PubMed:17382883, PubMed:18477612).
Molecular function
Hydrolase
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IF, IHC-P, WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IF, IP, FC
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For Research Use Only. Not For Clinical Use.