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ATG9A
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.
Protein class
Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets (PubMed:32610138, PubMed:33106659). Interacts (via cytoplasmic its C-terminus) with ATG2A (PubMed:32610138, PubMed:33106659). Interacts with SUPT20H (PubMed:19893488). Interacts (via the tyrosine-based sorting signal motif) with AP4M1; promoting association with the AP-4 complex (PubMed:29180427). Interacts with ARFIP1 and ARFIP2 (PubMed:30917996). Interacts with PI4K2A and PI4KB (PubMed:30917996). Interacts with ATG4A; the interaction is direct and promotes ATG9A trafficking (PubMed:33773106).
More Types Infomation
- Rabbit Anti-ATG9A Recombinant Antibody (clone AFY0065) (MOR-0094-FY)
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- Species Reactivity: Human, Bovine, Canine
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
- Rabbit Anti-ATG9A Recombinant Antibody (clone CBACN-052) (MRO-0138-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP
- Rabbit Anti-ATG9A Recombinant Antibody (VS3-WK1046) (VS3-WK1046)
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IHC, IP
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For Research Use Only. Not For Clinical Use.