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ATOX1

This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Proximal tubular cells, Hepatocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with ATP7B (PubMed:10966647). Interacts with ATP7A (PubMed:21667063, PubMed:19453293).

Molecular function

Chaperone

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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