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ATP1B4

This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene.
Protein class

Metabolic proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Skeletal myocytes, Cardiomyocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Not detected

Interaction

Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1 (By similarity). According to PubMed:17592128, does not associate with known Na,K-ATPase alpha-subunits.

More Types Infomation

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