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ATP4B
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase.
Protein class
FDA approved drug targets, Metabolic proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Gastric mucus-secreting cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
The ATPase pump is composed of two subunits: alpha (catalytic) and beta (regulatory). Interacts with alpha subunit ATP12A; this interaction is required for the formation of a functionally active pump and targeting at the plasma membrane (By similarity). Interacts (via N-terminus) with alpha subunit ATP4A (via the P-domain) (By similarity).
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
Related Diseases
Morphine Addiction
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
- Mouse Anti-ATP4B Recombinant Antibody (clone 2G11) (NEUT-921CQ)
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- Species Reactivity: Human, Mouse, Canine, Porcine, Rat, Guinea pig, Rabbit, Bovine, Mustelid
- Type: Mouse IgG1
- Application: Block, FC, ICC, IF, IHC, IHC-Fr, IHC-P, IP, WB, ChIP
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For Research Use Only. Not For Clinical Use.