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ATP7A
ATP7A (ATPase Copper Transporting Alpha) is a Protein Coding gene. This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. Diseases associated with ATP7A include Menkes Disease and Occipital Horn Syndrome.
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Ionocytes, Microglial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer. Interacts with PDZD11 (PubMed:16051599). Interacts with ATOX1 and COMMD1 (PubMed:21667063, PubMed:19453293, PubMed:31283225). Interacts with TYRP1 (By similarity). Directly interacts with SOD3; this interaction is copper-dependent and is required for SOD3 activity.
Molecular function
Translocase
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
Related Diseases
Morphine Addiction
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- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA, WB, IP, IF, IHC-P
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ICC, IF, IHC, IP
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IF, ICC, IHC-P, FC
- Rabbit Anti-ATP7A Recombinant Antibody (clone rL60/4) (VS-0422-LC78)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: IB, IHC, IP
- Human Anti-ATP7A Recombinant Antibody (clone hL60/4) (VS-0422-LC77)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: IB, IHC, IP
- Rat Anti-ATP7A Recombinant Antibody (clone rtL60/4) (VS-0422-LC76)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: IB, IHC, IP
- Chicken Anti-ATP7A Polyclonal IgY (BRD-0062MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.