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ATRIP
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with ATR (By similarity). Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single-stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP.
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: IF, WB
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For Research Use Only. Not For Clinical Use.