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AZU1

This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Protein class

Enzymes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Endometrial ciliated cells, Erythroid cells, Spermatogonia, Skeletal myocytes, Breast myoepithelial cells, Breast glandular cells, Respiratory ciliated cells)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enriched (THP-1)

Molecular function

Antibiotic, Antimicrobial, Heparin-binding, Serine protease homolog

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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