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B3GAT1

The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized.
Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Muller glia cells, Oligodendrocytes, Excitatory neurons, Bipolar cells, Oligodendrocyte precursor cells, Inhibitory neurons, Astrocytes)

Immune cell specificity

Immune cell enhanced (gdT-cell)

Cell line specificity

Cell line enhanced (AF22, HMC-1, NTERA-2, SH-SY5Y)

Interaction

Homodimer. Interacts with SAR1A.

Molecular function

Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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