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BACH2

Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1.
Protein class

Disease related genes, Human disease related genes, Plasma proteins, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Group enriched (Inhibitory neurons, Oligodendrocytes, Horizontal cells, Oligodendrocyte precursor cells, Excitatory neurons, B-cells, Astrocytes)

Immune cell specificity

Immune cell enhanced (naive B-cell)

Cell line specificity

Group enriched (Daudi, U-698)

Interaction

Homodimer; disulfide-linked (PubMed:22194330). Heterodimer of BACH2 and Maf-related transcription factors (By similarity).

Molecular function

Activator, DNA-binding, Repressor

More Types Infomation

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