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BAMBI

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.
Protein class

Plasma proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Granulosa cells, Breast glandular cells, Breast myoepithelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (CACO-2, SK-MEL-30, SuSa)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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