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BCL3
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Disease related genes, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Basal squamous epithelial cells, Squamous epithelial cells)
Immune cell specificity
Group enriched (neutrophil, eosinophil)
Cell line specificity
Cell line enhanced (HDLM-2, Karpas-707, SiHa)
Interaction
Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD (By similarity).
Molecular function
Activator
More Types Infomation
Related Signaling Pathways
TNF Signaling Pathway
- Mouse Anti-BCL3 Recombinant Antibody (clone 2F9) (MOB-0246CT)
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: IF, IHC-Fr, IHC-P
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For Research Use Only. Not For Clinical Use.