Intracellular
Cell type enhanced (Langerhans cells, monocytes, Basal respiratory cells)
Low immune cell specificity
Cell line enhanced (MCF7)
Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2 (By similarity). Interacts with PLEKHN1 (PubMed:29531808). [BH3-interacting domain death agonist]: Interacts with humanin; forms fibers with humanin which results in BID conformational changes and sequestering of BID into the fibers, preventing BID activation. [BH3-interacting domain death agonist p15]: Interacts with ITCH (PubMed:20392206). Interacts with humanin; the interaction prevents BID-induced apoptosis (PubMed:15661737). Interacts with MTCH2 (By similarity).
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For Research Use Only. Not For Clinical Use.