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BIN1
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal tubular cells, Oligodendrocytes, NK-cells, Hofbauer cells)
Immune cell specificity
Group enriched (T-reg, memory CD4 T-cell, memory CD8 T-cell, gdT-cell, naive B-cell, NK-cell, naive CD4 T-cell, naive CD8 T-cell, memory B-cell, MAIT T-cell)
Cell line specificity
Cell line enhanced (RPTEC TERT1)
Interaction
Heterodimer with AMPH (By similarity). Binds SH3GLB1 (By similarity). Interacts (via SH3 domain) with DNM1. Interacts with SYNJ1 (By similarity). Interacts (via SH3 domain) with DNM2 (PubMed:17676042). Isoform IIA interacts with CLTC. Isoform IIB does not interact with CLTC. Isoform IIC1 does not interact with CLTC. Isoform IIC2 does not interact with CLTC (PubMed:9603201). Interacts with AP2A2. Interacts with AP2B1 (By similarity). Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2 (By similarity). Interacts with BIN2 (PubMed:10903846). Interacts with SNX4 (PubMed:12668730). Interacts (via BAR domain) with BACE1 (PubMed:27179792). Binds (via BAR domain) F-actin (PubMed:28893863). (Microbial infection) Interacts (SH3 domain) with HCV NS5A.
Molecular function
Developmental protein
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IF, FC, IP
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
- Mouse Anti-BIN1 Recombinant Antibody; scFv Fragment (HPAB-0090-CN-S(P)) (HPAB-0090-CN-S(P))
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- Species Reactivity: Human, Dog
- Type: Mouse scFv
- Application: ELISA
- Rabbit Anti-BIN1 Recombinant Antibody; scFv Fragment (HPAB-0089-CN-S(P)) (HPAB-0089-CN-S(P))
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- Species Reactivity: Human, Dog
- Type: Rabbit scFv
- Application: ELISA
- Rabbit Anti-BIN1 Recombinant Antibody; scFv Fragment (HPAB-0088-CN-S(P)) (HPAB-0088-CN-S(P))
-
- Species Reactivity: Human, Dog
- Type: Rabbit scFv
- Application: ELISA
- Mouse Anti-BIN1 Recombinant Antibody; Fab Fragment (HPAB-0090-CN-F(E)) (HPAB-0090-CN-F(E))
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- Species Reactivity: Human, Dog
- Type: Mouse Fab
- Application: ELISA
- Rabbit Anti-BIN1 Recombinant Antibody; Fab Fragment (HPAB-0089-CN-F(E)) (HPAB-0089-CN-F(E))
-
- Species Reactivity: Human, Dog
- Type: Rabbit Fab
- Application: ELISA
- Rabbit Anti-BIN1 Recombinant Antibody; Fab Fragment (HPAB-0088-CN-F(E)) (HPAB-0088-CN-F(E))
-
- Species Reactivity: Human, Dog
- Type: Rabbit Fab
- Application: ELISA
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-F, IHC-P, ICC, IF
- Mouse Anti-BIN1 Recombinant Antibody (HPAB-0090-CN) (HPAB-0090-CN)
-
- Species Reactivity: Human, Dog
- Type: Mouse IgG
- Application: ELISA
- Rabbit Anti-BIN1 Recombinant Antibody (HPAB-0089-CN) (HPAB-0089-CN)
-
- Species Reactivity: Human, Dog
- Type: Rabbit IgG
- Application: ELISA
- Rabbit Anti-BIN1 Recombinant Antibody (HPAB-0088-CN) (HPAB-0088-CN)
-
- Species Reactivity: Human, Dog
- Type: Rabbit IgG
- Application: ELISA
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For Research Use Only. Not For Clinical Use.