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BMP4
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Fibroblasts, Hepatic stellate cells, Skeletal myocytes, Basal squamous epithelial cells, Pancreatic endocrine cells, Syncytiotrophoblasts)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Cell line enhanced (CACO-2, CAPAN-2, Hep G2, OE19, SuSa)
Interaction
Homodimer; disulfide-linked (By similarity). Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition (By similarity). Interacts with SOSTDC1. Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631). Interacts with type I receptor BMPR1A (PubMed:8006002). Interacts with type II receptor BMPR2 (PubMed:29212066). Interacts with FSTL1; this interaction inhibits the activation of the BMP4/Smad1/5/8 signaling pathway (PubMed:29212066). Interacts with SCUBE3 (PubMed:33308444).
Molecular function
Cytokine, Developmental protein, Growth factor
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IHC
- Mouse Anti-BMP4 Recombinant Antibody (clone 20G5C5) (MOB-1495MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, ICC, WB
- Rat Anti-BMP4 Recombinant Antibody (clone CBL387) (NEUT-055CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG1
- Application: Neut
- Mouse Anti-BMP4 Recombinant Antibody (clone CBL987) (NEUT-054CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: ELISA, WB, IHC, Neut
- Mouse Anti-BMP4 Recombinant Antibody (clone CBL816) (NEUT-053CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, Neut, ELISA
- Mouse Anti-BMP4 Recombinant Antibody (clone CBL815) (NEUT-052CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: Neut, WB
- Mouse Anti-BMP4 Recombinant Antibody (clone 3H2) (NEUT-051CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: ELISA, Neut, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC, IP, FC
- Anti-Human BMP4 Recombinant Antibody (TAB-069CL)
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- Derivation: Human
- Species Reactivity: Human
- Type: Antibody
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- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IF
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse IgG1
- Application: WB, ICC, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
- Mouse Anti-BMP4 Recombinant Antibody (TAB-1273CL) (TAB-1273CL)
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FuncS
- Mouse Anti-BMP4 Recombinant Antibody (TAB-1272CL) (TAB-1272CL)
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- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: FuncS
- Recombinant Llama Anti-BMP4 Single Domain Antibody (E7) (HPAB-0356-YC-VHH)
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- Derivation: The VHH library
- Species Reactivity: Human
- Type: Llama VHH
- Application: Inhib, SPR
- Recombinant Llama Anti-BMP4 Single Domain Antibody (C8) (HPAB-0355-YC-VHH)
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- Derivation: The VHH library
- Species Reactivity: Human
- Type: Llama VHH
- Application: FuncS, SPR, Activ
- Mouse Anti-BMP4 Recombinant Antibody; scFv Fragment (TAB-1273CL-S(P)) (TAB-1273CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS
- Mouse Anti-BMP4 Recombinant Antibody; scFv Fragment (TAB-1272CL-S(P)) (TAB-1272CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS
- Recombinant Llama Anti-BMP4 Single Domain Antibody (C4C4) (HPAB-0357-YC-VHH)
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- Derivation: The VHH library
- Species Reactivity: Human
- Type: Llama VHH
- Application: Inhib, SPR
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For Research Use Only. Not For Clinical Use.