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BMP7

This gene encodes a member of the transforming growth factor-beta (TGF-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate each subunit of the mature homodimer, which plays a role in bone, kidney and brown adipose tissue development. This protein induces ectopic bone formation and may promote fracture healing in human patients.
Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Cytotrophoblasts, Oligodendrocyte precursor cells, Astrocytes, Syncytiotrophoblasts, Basal squamous epithelial cells, Squamous epithelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (Daudi, MCF7, OE19, RPMI-8226, SK-BR-3, U-698)

Interaction

Homodimer; disulfide-linked. Interacts with SOSTDC1 (PubMed:15020244). Interacts with TWSG1 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631). Interacts with type I receptor ACVR1 (PubMed:9748228). Interacts with type II receptor ACVR2A (PubMed:12667445). Interacts with NOG; this interaction inhibits canonical BMP signaling (PubMed:12478285). Interacts with SCUBE3 (PubMed:33308444).

Molecular function

Cytokine, Developmental protein, Growth factor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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