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BMP8B

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.
Predicted location

Secreted

Single cell type specificity

Group enriched (Late spermatids, Early spermatids, Plasma cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (THP-1, U-266/70, U-266/84, WM-115)

Interaction

Homodimer; disulfide-linked.

Molecular function

Cytokine, Developmental protein, Growth factor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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