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C5AR1
C5AR1 (Complement C5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and complement component C5a binding. An important paralog of this gene is C5AR2.
Protein class
CD markers, G-protein coupled receptors, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Macrophages, Kupffer cells, Hofbauer cells, Langerhans cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (A549, CAPAN-2, HMC-1, U-87 MG, U-937)
Interaction
Homodimer. May also form higher-order oligomers (PubMed:12835319). Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR (PubMed:12464600). Interacts (via N-terminal domain) with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response (PubMed:15153520, PubMed:15542591, PubMed:21706042).
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
- Mouse Anti-C5AR1 Recombinant Antibody (clone D10) (FAMAB-1724CQ)
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- Species Reactivity: Guinea Pig
- Type: Mouse IgG1
- Application: WB, ELISA
- Mouse Anti-C5AR1 Recombinant Antibody (clone Q23/2) (MOB-0677MZ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, WB
- Rat Anti-C5AR1 Recombinant Antibody (clone 20/70) (NEUT-097CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2b, κ
- Application: FC, Block
- Rat Anti-C5AR1 Recombinant Antibody (clone CBL744) (NEUT-098CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: WB, ELISA(Cap), Neut
- Recombinant Mouse Anti-C5AR1 Antibody (NEUT-093CQ)
-
- Species Reactivity: Human, Rabbit
- Type: IgG2a
- Application: FC, IHC, Neut
- Mouse Anti-C5AR1 Recombinant Antibody (clone CBL266) (NEUT-094CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: Neut, FC, ELISA
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC
- Mouse Anti-C5AR1 Recombinant Antibody (clone CBL218) (NEUT-095CQ)
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- Species Reactivity: Human, Rabbit
- Type: Mouse IgG2a
- Application: FC, IHC, Neut
- Mouse Anti-C5AR1 Recombinant Antibody (clone CBL759) (NEUT-096CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, CyTOF, Neut
- Human Anti-C5AR1 Recombinant Antibody; scFv Fragment (TAB-1385CL-S(P)) (TAB-1385CL-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS
- Human Anti-C5AR1 Recombinant Antibody; scFv Fragment (TAB-1384CL-S(P)) (TAB-1384CL-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: FC, Inhib
- Mouse Anti-C5AR1 Recombinant Antibody; scFv Fragment (TAB-1390CL-S(P)) (TAB-1390CL-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, Inhib
- Anti-Human C5AR1 Recombinant Antibody (TAB-085CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
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- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA
- Mouse Anti-C5AR1 Recombinant Antibody; scFv Fragment (HPAB-M0021-YC-S(P)) (HPAB-M0021-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, Block
- Mouse Anti-C5AR1 Recombinant Antibody; scFv Fragment (HPAB-M0020-YC-S(P)) (HPAB-M0020-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, Block
- Mouse Anti-C5AR1 Recombinant Antibody; scFv Fragment (HPAB-M0019-YC-S(P)) (HPAB-M0019-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, Block
- Mouse Anti-C5AR1 Recombinant Antibody; Fab Fragment (HPAB-M0021-YC-F(E)) (HPAB-M0021-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, Block
- Mouse Anti-C5AR1 Recombinant Antibody; Fab Fragment (HPAB-M0020-YC-F(E)) (HPAB-M0020-YC-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, Block
- Mouse Anti-C5AR1 Recombinant Antibody; Fab Fragment (HPAB-M0019-YC-F(E)) (HPAB-M0019-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, Block
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For Research Use Only. Not For Clinical Use.