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C7
C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Group enriched (Leydig cells, Hepatic stellate cells, Fibroblasts, Theca cells, Sertoli cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (ASC diff, HHSteC, HSkMC, SH-SY5Y)
Interaction
Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes. MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.
More Types Infomation
Related Diseases
Systemic Lupus Erythematosus
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC, FC
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For Research Use Only. Not For Clinical Use.