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CA14

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.
Protein class

Enzymes, FDA approved drug targets, Metabolic proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Muller glia cells, Cardiomyocytes, Melanocytes, Oligodendrocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (AF22, AN3-CA, NTERA-2, SK-MEL-30)

Molecular function

Lyase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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