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CANX
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (hTERT-HME1, SK-MEL-30)
Interaction
Interacts with MAPK3/ERK1 (By similarity). Interacts with KCNH2 (PubMed:16361248). Associates with ribosomes (By similarity). Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins (PubMed:22314232). Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1 (PubMed:23826168). Interacts with PPIB (PubMed:20801878). Interacts with ZNRF4 (PubMed:21205830). Interacts with SMIM22 (PubMed:29765154). Interacts with TMX2 (PubMed:31735293). Interacts with TMEM35A/NACHO (By similarity). Interacts with CHRNA7 (PubMed:32783947). (Microbial infection) Interacts with HBV large envelope protein, isoform L. (Microbial infection) Interacts with HBV large envelope protein, isoform M; this association may be essential for isoform M proper secretion.
Molecular function
Chaperone
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: FC, ICC, IP, ELISA
- Rabbit Anti-CANX Recombinant Antibody (clone AFY0050) (MOR-0079-FY)
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- Species Reactivity: Human, Mouse, Rat (P)
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
- Rabbit Anti-CANX Recombinant Antibody (clone CBACN-079) (MRO-0214-CN)
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, FC, ICC, IF, IHC
- Rabbit Anti-CANX Polyclonal Antibody (MRO-1711-CN) (MRO-1711-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC, FC
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P, IP, WB
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, FC
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB, IHC, IP, IF
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB, IHC, IP, IF
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB, IHC, IP, IF
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, IHC, ICC, FC, ELISA
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB, IF, FC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB, FC
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IF, ELISA
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