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CASP9
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
Protein class
Cancer-related genes, Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts (inactive form) with EFHD2. Interacts with HAX1. Interacts with BIRC2/c-IAP1, XIAP/BIRC4, BIRC5/survivin, BIRC6/bruce and BIRC7/livin. Interacts with ABL1 (via SH3 domain); the interaction is direct and increases in the response of cells to genotoxic stress and ABL1/c-Abl activation. Interacts with BCL2L10 (PubMed:19255499). Interacts with NleF from pathogenic E.coli.
Molecular function
Hydrolase, Protease, Thiol protease
More Types Infomation
- Rabbit Anti-CASP9 Recombinant Antibody (clone CBACN-461) (MRO-1272-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, FC
- Mouse Anti-CASP9 Recombinant Antibody (clone 3-33) (MOB-0422MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IP, WB
- Rabbit Anti-CASP9 Recombinant Antibody (clone CBACN-096) (MRO-0247-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IP
- Rabbit Anti-CASP9 Recombinant Antibody (clone CBACN-095) (MRO-0246-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, FC, IP, IHC-Fr
- Rabbit Anti-CASP9 Polyclonal Antibody (MRO-1722-CN) (MRO-1722-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IF, IHC, IP
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: ELISA, WB, IP
-
- Derivation: Mouse
- Species Reactivity: Human, Transfected
- Type: Mouse IgG1
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
- Rabbit Anti-CASP9 Recombinant Antibody (VS3-CJ1045) (VS3-CJ1045)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IP
- Mouse Anti-CASP9 Recombinant Antibody (VS3-CJ1044) (VS3-CJ1044)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, IP
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Human, Mouse, Rat, chicken
- Type: Mouse IgG
- Application: WB, IHC-P, IF/ICC, IP
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
-
- Species Reactivity: Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IF, FC
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