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CCNE1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.
Protein class

Cancer-related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Extravillous trophoblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO)

Interaction

Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (PubMed:15660127). Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1 (PubMed:15178429). Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (PubMed:21952639). Interacts with INCA1 (PubMed:21540187).

Molecular function

Cyclin

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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