Intracellular
Cell type enhanced (Erythroid cells)
Low immune cell specificity
Low cell line specificity
Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF (PubMed:20596027). Interacts with SKP1 (PubMed:8706131, PubMed:12122006). Interacts with CUL1 (PubMed:26818844). Interacts with CCNB1; interaction is required for nuclear localization of CCNB1 (PubMed:10716937, PubMed:20596027). Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway (PubMed:22441691). Interacts (via the Cyclin N-terminal domain) with MYBL2/BMYB (PubMed:25557911). Interacts with FZR1/CDH1 (via N-terminus) (PubMed:27653696). Interacts with RRM2 (via Cy motif and when phosphorylated at 'Thr-33'); the interaction occurs exclusively in G2 and early M (PubMed:22632967). Interacts with CDC6 (via Cy motif); the interaction takes place during G2 and M phase (PubMed:26818844).
Cyclin
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For Research Use Only. Not For Clinical Use.