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CCR1

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.
Protein class

CD markers, G-protein coupled receptors, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Group enriched (Kupffer cells, Hofbauer cells, Extravillous trophoblasts, Macrophages, monocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (Karpas-707, RPMI-8226, U-266/70, U-266/84)

Interaction

Interacts with CREB3.

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation

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