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CD101

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.
Protein class

CD markers

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Macrophages, Kupffer cells, Sertoli cells, monocytes, T-cells, Skeletal myocytes, Oligodendrocyte precursor cells)

Immune cell specificity

Immune cell enhanced (eosinophil)

Cell line specificity

Cell line enriched (HMC-1)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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