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CD3G
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency.
Protein class
CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (T-cells, dendritic cells)
Immune cell specificity
Group enriched (naive CD8 T-cell, gdT-cell, T-reg, memory CD8 T-cell, naive CD4 T-cell, memory CD4 T-cell, MAIT T-cell)
Cell line specificity
Group enriched (JURKAT, MOLT-4)
Interaction
The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
Molecular function
Receptor
More Types Infomation
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC
- Rabbit Anti-CD3G Recombinant Antibody (clone JB38-29) (MRO-0302-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC, FC, IP
- Mouse Anti-CD3G Recombinant Antibody (clone MEM57) (VS-0323-XY4)
-
- Species Reactivity: Human
- Type: Mouse IgG2
- Application: ELISA
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For Research Use Only. Not For Clinical Use.