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CD6

Engineered Antibody
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule.
CD6
Protein class

CD markers

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (T-cells, NK-cells, dendritic cells, Plasma cells)

Immune cell specificity

Group enriched (memory CD4 T-cell, memory CD8 T-cell, naive CD4 T-cell, gdT-cell, T-reg, naive CD8 T-cell, MAIT T-cell)

Cell line specificity

Group enriched (JURKAT, MOLT-4)

Interaction

Interacts (via extracellular domain) with ALCAM/CD166 (via extracellular domain) (PubMed:15048703, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:26146185). Interacts with the TCR/CD3 complex subunit CD3E (PubMed:15294938). Interacts (via tyrosine phosphorylated C-terminus) with LCP2 (via SH2 domain) (PubMed:16914752). Interacts with VAV1 (By similarity). Interacts (via glycosylated extracellular domain) with LGALS1 and LGALS3 (PubMed:24945728). Interaction with LGALS1 or LGALS3 inhibits interaction with ALCAM (PubMed:24945728).

More Types Infomation

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