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CDC42EP2
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells, Pancreatic endocrine cells, Ductal cells)
Immune cell specificity
Group enriched (neutrophil, intermediate monocyte, non-classical monocyte, classical monocyte)
Cell line specificity
Cell line enhanced (HHSteC, PC-3, U-2197)
Interaction
Interacts with RHOQ and CDC42 in a GTP-dependent manner, and with SEPT7.
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.