CEBPA

Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors

Intracellular

Cell type enhanced (Syncytiotrophoblasts, Suprabasal keratinocytes, Hepatocytes, Distal enterocytes, Hofbauer cells)

Group enriched (basophil, non-classical monocyte, intermediate monocyte, classical monocyte, myeloid DC)

Cell line enhanced (BEWO, Hep G2, NB-4, THP-1, U-937)

Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPB, CEBPD, CEBPE and CEBPG (By similarity). Interacts with PRDM16 (By similarity). Interacts with UBN1 (PubMed:10725330). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity). Interacts with the complex TFDP2:E2F1; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (PubMed:20176812). Interacts with RB1 (PubMed:15107404). Interacts (when phosphorylated at SER-190) with CDK2, CDK4, E2F4 and SMARCA2 (PubMed:15107404). Interacts with SREBPF1 (By similarity). Interacts with FOXO1 (via the Fork-head domain); the interaction increases when FOXO1 is deacetylated (By similarity). Interacts with SIX1 (PubMed:27923061). Interacts (via recognition sequence) with TRIB1 (PubMed:20410507, PubMed:26455797). [Isoform 1]: Interacts with TAF1A and UBTF. [Isoform 4]: Interacts with TAF1A and UBTF (PubMed:20075868). Interacts with NPM1 (PubMed:20075868). (Microbial infection) Interacts with HBV protein X.

Activator, Developmental protein, DNA-binding