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CFP
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (monocytes, Kupffer cells, Macrophages, Langerhans cells, Hepatic stellate cells)
Immune cell specificity
Group enriched (intermediate monocyte, classical monocyte, myeloid DC, non-classical monocyte, neutrophil)
Cell line specificity
Cell line enhanced (EFO-21, HEL, HMC-1, NB-4, U-937)
Interaction
In plasma, properdin exists as dimers, trimers or tetramers in the relative proportions of 26:54:20 (PubMed:20382442, PubMed:15491616, PubMed:28264884, PubMed:31507604). Interacts with the pro-C3-convertase enzyme complex (C3b-Bb) comprised of Complement C3 beta chain (C3b) and the Complement factor B Bb fragment (Bb), where it binds (via its TSP type-1 5 domain) with C3b and Bb (PubMed:28264884, PubMed:31507604). This interaction stabilizes the complex and allows it to become the active C3-convertase enzyme complex (C3b-Bb-FP) (PubMed:28264884, PubMed:31507604). Interacts with C3b (PubMed:28264884, PubMed:31507604). Interacts with CFB (PubMed:31507604).
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, IHC, FuncS
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- Species Reactivity: Human
- Application: ELISA, FuncS, IHC-Fr
- Recombinant Human Anti-CFP Antibody scFv Fragment (8E2) (PABX-057-S (P))
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- Derivation: Human
- Species Reactivity: Monkey
- Type: scFv
- Application: FC, FuncS
- Recombinant Human Anti-CFP Antibody Fab Fragment (8E2) (PABX-057-F (E))
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- Derivation: Human
- Species Reactivity: Monkey
- Type: Fab
- Application: FC, FuncS
- Recombinant Human Anti-CFP Antibody (8E2) (PABX-057)
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- Derivation: Human
- Species Reactivity: Monkey
- Type: IgG
- Application: IF
- Mouse Anti-CFP Recombinant Antibody (clone CB67YJ) (MOB-026YJL)
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, IHC-P, ELISA
- Mouse Anti-CFP Recombinant Antibody (TAB-1080CL) (TAB-1080CL)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
- Mouse Anti-CFP Recombinant Antibody (TAB-1079CL) (TAB-1079CL)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
- Mouse Anti-CFP Recombinant Antibody (TAB-1078CL) (TAB-1078CL)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
- Mouse Anti-CFP Recombinant Antibody (TAB-1077CL) (TAB-1077CL)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
- Anti-Human CFP Recombinant Antibody (TAB-1076CL)
-
- Type: Human antibody
- Application: ELISA
- Mouse Anti-CFP Recombinant Antibody; scFv Fragment (TAB-1081CL-S(P)) (TAB-1081CL-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-CFP Recombinant Antibody; scFv Fragment (TAB-1080CL-S(P)) (TAB-1080CL-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
- Anti-Human Properdin Recombinant Antibody (TAB-240CT)
-
- Derivation: XenoMouse
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
- Mouse Anti-CFP Recombinant Antibody; Fab Fragment (TAB-1081CL-F(E)) (TAB-1081CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-CFP Recombinant Antibody; Fab Fragment (TAB-1080CL-F(E)) (TAB-1080CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Mouse Anti-CFP Recombinant Antibody; Fab Fragment (TAB-1079CL-F(E)) (TAB-1079CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
- Mouse Anti-CFP Recombinant Antibody; Fab Fragment (TAB-1078CL-F(E)) (TAB-1078CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
- Mouse Anti-CFP Recombinant Antibody; Fab Fragment (TAB-1077CL-F(E)) (TAB-1077CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
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