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CHRM2

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
Protein class

Disease related genes, FDA approved drug targets, G-protein coupled receptors

Predicted location

Membrane

Single cell type specificity

Group enriched (Inhibitory neurons, Cardiomyocytes, Excitatory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (fHDF/TERT166)

Interaction

Interacts with ARRB1 and ARRB2. Interacts with RACK1; the interaction regulates CHRM2 internalization.

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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