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CHRM3

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.
Protein class

Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Group enriched (Excitatory neurons, Inhibitory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (RPMI-8226, SH-SY5Y, U-266/70, U-266/84)

Interaction

Homodimer; the dimers can form tetramers (PubMed:23521066). Interacts with NALCN (By similarity). Interacts with TMEM147 (PubMed:21056967).

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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