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CISH

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
CISH
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Distal tubular cells, Proximal tubular cells, Alveolar cells type 2)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enriched (HDLM-2)

Interaction

Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR).

Molecular function

Signal transduction inhibitor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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