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CITED2
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Plasma cells)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enhanced (BJ, fHDF/TERT166)
Interaction
Interacts (via C-terminus) with SMAD2. Interacts (via C-terminus) with SMAD3 (via MH2 domain). Interacts with LHX2 (via LIM domains). Interacts with WT1 (By similarity). Interacts (via C-terminus) with EP300 (via CH1 domain); the interaction is stimulated in response to hypoxia. Interacts with PPARA. Interacts (via C-terminus) with TFAP2A, TFAP2B and TFAP2C.
Molecular function
Activator, Developmental protein, Repressor
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.