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CITED4
The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Endometrial ciliated cells, Cholangiocytes, Breast myoepithelial cells, Glandular and luminal cells, Breast glandular cells, Basal prostatic cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (RPTEC TERT1, THP-1)
Interaction
Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms.
Molecular function
Activator
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.