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CLDN6

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space.
Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Extravillous trophoblasts, Syncytiotrophoblasts, Cytotrophoblasts, Ductal cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (BEWO, CACO-2, NTERA-2, SuSa)

Interaction

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with CLDN1, CD81 and OCLN (PubMed:20375010).

Molecular function

Host cell receptor for virus entry, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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