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CLEC4A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
Protein class

CD markers

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Langerhans cells, monocytes, Macrophages, Kupffer cells)

Immune cell specificity

Group enriched (classical monocyte, myeloid DC, neutrophil, basophil, intermediate monocyte, non-classical monocyte)

Cell line specificity

Cell line enhanced (ASC TERT1)

Interaction

May interact with PTPN6 via its ITIM motif.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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