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CLEC5A
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Langerhans cells, Macrophages, Hofbauer cells)
Immune cell specificity
Immune cell enriched (classical monocyte)
Cell line specificity
Group enriched (HL-60, U-937)
Interaction
Monomer (PubMed:21566123). Homodimer (PubMed:21566123). The majority of CLEC5A is expressed as a monomeric form on macrophages (PubMed:21566123). Interacts with TYROBP/DAP12 (PubMed:10449773). The interaction with TYROBP is required for CLEC5A cell surface expression (PubMed:10449773). Interacts with HCST/DAP10 (By similarity). Forms a CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP (By similarity). (Microbial infection) Interacts with dengue virus envelope protein E (PubMed:18496526, PubMed:21566123).
Molecular function
Host cell receptor for virus entry, Receptor
More Types Infomation
- Human Anti-CLEC5A Antibody, mRNA (TAB-175CL-mRNA)
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- Species Reactivity: Human
- Mouse Anti-CLEC5A Recombinant Antibody (HPAB-0962-FY) (HPAB-0962-FY)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC
- Human Anti-CLEC5A Recombinant Antibody; scFv Fragment (HPAB-0313LY-S(P)) (HPAB-0313LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: Inhib, FC, ELISA, IP
- Mouse Anti-CLEC5A Recombinant Antibody; scFv Fragment (HPAB-0962-FY-S(P)) (HPAB-0962-FY-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Human Anti-CLEC5A Recombinant Antibody (HPAB-0313LY) (HPAB-0313LY)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: Inhib, FC, ELISA, IP
- Mouse Anti-CLEC5A Recombinant Antibody; Fab Fragment (HPAB-0962-FY-F(E)) (HPAB-0962-FY-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB, FC
- Human Anti-CLEC5A Recombinant Antibody; Fab Fragment (HPAB-0313LY-F(E)) (HPAB-0313LY-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody; scFv Fragment (HPAB-0312LY-S(P)) (HPAB-0312LY-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody; scFv Fragment (HPAB-0311LY-S(P)) (HPAB-0311LY-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody; scFv Fragment (HPAB-0310LY-S(P)) (HPAB-0310LY-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody; scFv Fragment (HPAB-0309LY-S(P)) (HPAB-0309LY-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody; Fab Fragment (HPAB-0312LY-F(E)) (HPAB-0312LY-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody; Fab Fragment (HPAB-0311LY-F(E)) (HPAB-0311LY-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody; Fab Fragment (HPAB-0310LY-F(E)) (HPAB-0310LY-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody; Fab Fragment (HPAB-0309LY-F(E)) (HPAB-0309LY-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody (HPAB-0312LY) (HPAB-0312LY)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody (HPAB-0311LY) (HPAB-0311LY)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody (HPAB-0310LY) (HPAB-0310LY)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: Inhib, FC, ELISA, IP
- Human Anti-CLEC5A Recombinant Antibody (HPAB-0309LY) (HPAB-0309LY)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: Inhib, FC, ELISA, IP
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For Research Use Only. Not For Clinical Use.