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CNN1

CNN1 (Calponin 1) is a Protein Coding gene. Diseases associated with CNN1 include Laryngeal Small Cell Carcinoma and Infantile Digital Fibromatosis. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Endothelin Pathways. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is CNN3.
Protein class

Cancer-related genes

Predicted location

Intracellular

Single cell type specificity

Group enriched (Late spermatids, Early spermatids, Peritubular cells, Breast myoepithelial cells, Smooth muscle cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BJ, BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HBF TERT88, K-562, SuSa, U-2 OS)

Interaction

Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.

Molecular function

Actin-binding, Calmodulin-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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