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CNR1
Enables cannabinoid receptor activity. Involved in several processes, including positive regulation of acute inflammatory response; regulation of secretion by cell; and response to alkaloid. Located in membrane raft and plasma membrane. Colocalizes with intracellular membrane-bounded organelle. Used to study several diseases, including Parkinsonism; diabetic neuropathy; impotence; obesity; and peptic ulcer disease. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (cannabinoid receptor 1).
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Sertoli cells, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (ASC diff, HSkMC)
Interaction
Interacts (via C-terminus) with CNRIP1; this interaction attenuates constitutive, but not agonist-dependent, inhibition of voltage-gated Ca(2+) channels in neurons (PubMed:17895407). Associates with G protein alpha subunits, including G(i) alpha-1/GNAI1, G(i) alpha-3/GNAI3 and G(o)-alpha/GNAO1; palmitoylation is important for interaction with GNAI3 and GNAO1 (PubMed:12237474).
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
- Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2992LY-F(E)) (HPAB-2992LY-F(E))
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: ELISA, WB, FC, FuncS
- Human Anti-CNR1 Recombinant Antibody (HPAB-2988LY) (HPAB-2988LY)
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: ELISA, WB, FC, FuncS
- Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2988LY-S(P)) (HPAB-2988LY-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB, FC, FuncS
- Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2987LY-F(E)) (HPAB-2987LY-F(E))
-
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: ELISA, WB, FC, FuncS
- Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2991LY-F(E)) (HPAB-2991LY-F(E))
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: ELISA, WB, FC, FuncS
- Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2987LY-S(P)) (HPAB-2987LY-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB, FC, FuncS
- Human Anti-CNR1 Recombinant Antibody (HPAB-2987LY) (HPAB-2987LY)
-
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: ELISA, WB, FC, FuncS
- Human Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-0124-YJ-S(P)) (HPAB-0124-YJ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, FuncS
- Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-0124-YJ-F(E)) (HPAB-0124-YJ-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, FuncS
- Human Anti-CNR1 Recombinant Antibody (HPAB-0124-YJ) (HPAB-0124-YJ)
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- Species Reactivity: Human
- Type: Human IgG2, κ
- Application: ELISA, FC, FuncS
- Human Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-0123-YJ-S(P)) (HPAB-0123-YJ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, FuncS
- Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-0123-YJ-F(E)) (HPAB-0123-YJ-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, FuncS
- Human Anti-CNR1 Recombinant Antibody (HPAB-0123-YJ) (HPAB-0123-YJ)
-
- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: ELISA, FC, FuncS
- Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-0122-YJ-S(P)) (HPAB-0122-YJ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, FuncS
- Mouse Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-0122-YJ-F(E)) (HPAB-0122-YJ-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, FuncS
- Mouse Anti-CNR1 Recombinant Antibody (HPAB-0122-YJ) (HPAB-0122-YJ)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC, FuncS
- Human Anti-CNR1 Recombinant Antibody; Fab Fragment (TAB-1492CL-F(E)) (TAB-1492CL-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: FC, FuncS
- Human Anti-CNR1 Recombinant Antibody; scFv Fragment (TAB-1492CL-S(P)) (TAB-1492CL-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: FC, FuncS
- Human Anti-CNR1 Recombinant Antibody (TAB-1492CL) (TAB-1492CL)
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- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG
- Application: FC, FuncS
-
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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For Research Use Only. Not For Clinical Use.