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COL3A1

COL3A1 (Collagen Type III Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL3A1 include Ehlers-Danlos Syndrome, Vascular Type and Acrogeria, Gottron Type. Among its related pathways are Integrin Pathway and ERK Signaling Gene Ontology (GO) annotations related to this gene include integrin binding and SMAD binding. An important paralog of this gene is COL2A1.
Protein class

Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Endometrial stromal cells, Fibroblasts, Smooth muscle cells, Theca cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, ASC diff, ASC TERT1, fHDF/TERT166, HHSteC, HSkMC)

Interaction

Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines. Interacts with ADGRG1 (PubMed:28258187).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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