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COL4A1

Engineered Antibody
COL4A1 (Collagen Type IV Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL4A1 include Retinal Arteries, Tortuosity Of and Schizencephaly. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent and extracellular matrix constituent conferring elasticity. An important paralog of this gene is COL4A5.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Extravillous trophoblasts, Sertoli cells, Smooth muscle cells, Adipocytes, Endothelial cells, Endometrial stromal cells)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Cell line enhanced (ASC diff, EFO-21, TIME)

Interaction

There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. Interacts with EFEMP2 (By similarity).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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