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CPE
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
Protein class
Enzymes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Sertoli cells, Rod photoreceptor cells, Astrocytes, Cone photoreceptor cells, Peritubular cells, Enteroendocrine cells, Bipolar cells, Muller glia cells, Smooth muscle cells, Leydig cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (Hep G2, SCLC-21H, SiHa, SuSa)
Interaction
Interacts with secretogranin III/SCG3.
Molecular function
Carboxypeptidase, Hydrolase, Metalloprotease, Protease
More Types Infomation
Related Diseases
Maturity Onset Diabetes of the Young
- Mouse Anti-CPE Recombinant Antibody (clone 38C2) (MOB-2336z)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, IF, IP
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
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For Research Use Only. Not For Clinical Use.